This page contains reference examples for whole authored book, whole edited book, republished book, and multivolume work. Ross, md4 1georgehuntingtoninstitute, technologypark, muenster, germany 2department of neurodegenerative diseases and hertieinstitute for clinical brain research, university of tuebingen, tuebingen, germany 3centre for molecular medicine and. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as alzheimers disease, stroke, migraine, multiple sclerosis, concussion, parkinsons disease and epilepsy. Behavioral changes are a central feature of hd and often cause considerable distress and difficulty to patients and their relatives. Behavioural change in huntingtons disease citation. List of books and articles about huntingtons disease. It is a brain disorder that causes certain types of neurons to become damaged, causing various parts of the brain to deteriorate and lose their function. The causative gene for huntingtons disease, hd, one of the first genes identified to cause an inherited disease, is located on chromosome 4. Huntingtons disease can attack just about anyone, but it is involved in the genetics of a family. The earliest symptoms are often subtle problems with mood or mental abilities. Huntingtons disease, also known as hd, was first described on february 14, 1872 by a man named george huntington, a family practitioner.
Genetic modifier for huntingtons disease progression. Huntingtons disease offers introduces this disease, detailing its history and progression, and discusses the search for the gene that. Understanding the role of genetics can help you recognize huntington disease in a patient with progressive motor disability. Huntingtons disease hd is a hereditary and progressive brain disorder. George huntingtons on chorea inside huntingtons disease. Books apa 6th referencing style guide library guides at aut. Huntingtons disease hd is a neurodegenerative genetic disorder that affects muscle coordination and leads to mental decline and behavioral disorders. The aim of the guide is to help carers and healthcare staff recognise and respond to the wide ranging symptoms of huntingtons, which affect the way people think, feel, speak, move, swallow and eat. Huntingtons disease is an inherited disease that causes the progressive breakdown degeneration of nerve cells in the brain. Huntingtons disease is an autosomal dominant, progressive neurodegenerative disease that typically manifests in adulthood. Crediting sources and formatting references according to the style of the american. A physicians guide to the management of huntingtons disease, 3rd ed, nance m, paulsen js, rosenblatt a, wheelock v eds, huntingtons disease society of america, 2011.
Huntingtons disease, his or her children have a 50 percent chance to inherit the mutant gene, and if one copy of the mutated gene is present, the symptoms will appear 1. Although symptoms may first show up in midlife, huntingtons can strike anyone. Huntingtons disease, or huntingtons chorea, is a progressive genetic disease marked by death of brain cells coupled with loss of muscular control and coordination, declining mental abilities, and erratic behavior. Hsc collaborates globally to to ensure the most uptodate information is available. Today, huntingtons disease is treatable, but it is still a devastating disease that has no cure, but researchers are working on longterm treatment for the disease. This includes both faulty voluntary actions and involuntary movements like jerking movements or trembling chorea. The disease is sometimes confused with chorea or st. This results in uncontrolled movements, loss of intellectual capabilities and behavioural disturbances. The bible, particularly the old testament, describes numerous occasions when god brought plagues and diseases on his. Symptoms of the disease can vary aggression, anger, antisocial behavior, apathy, depression, excitement, frustration. We have collaborated with st andrews healthcare to launch a mini guide to understanding the effects of huntingtons disease. Crediting sources and formatting references according to the style of the american psychological association apa. The disease is caused by a polymorphic cag repeat expansion, encoding an extended polyglutamine polyq tract, in. Huntington disease hd is a fatal, autosomal dominant neurodegenerative disorder.
Huntingtons disease news is strictly a news and information website about the disease. Zotero is a free tool, available to help you automatically format your bibliographies and organize all those articles, books. Book chapter apa 6th referencing style library guides at. A complete reference to a print book includes the following. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. The physician may ask the individual to undergo a brain imaging test. Huntington s disease is a rare, inherited disease that causes the progressive breakdown degeneration of nerve cells in the brain. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of hd, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of. Huntingtons disease is one of the wellstudied neurodegenerative conditions, a quite devastating and currently incurable one. The hereditary and debilitative nature of the disease means that many people are involved either directly or indirectly by this condition.
Huntington s disease is an inherited disease that causes the progressive breakdown degeneration of nerve cells in the brain. Huntingtons disease an overview sciencedirect topics. This book is the authors journey as wife, mother, breadwinner, caregiver and widowspouse survivor of huntingtons disease. Huntingtons disease and laboratory investigation of this disease. In 1993, the genetic mutation responsible for huntingtons disease hd was identified. This guide looks at how to create intext references, reference lists and bibliographies using the apa 6th style. Huntingtons disease has a broad impact on a persons functional abilities and usually results in movement, thinking cognitive and. The example of huntingtons disease huntingtons disease hd is a fatal, incurable genetic disease that runs in families. The recent identification of the faulty gene involved has made the diagnosis of this condition simpler. What does the bible say about pandemic diseasessicknesses. Huntingtons disease is a neurodegenerative condition and a person with this disorder will face difficulties in motor functions, cognitive deterioration, and psychiatric symptoms.
Huntingtons disease hd is an inherited disease that causes certain nerve cells in the brain to waste away. Early signs and symptoms can include irritability, depression, small involuntary movements, poor coordination, and trouble. Various outbreaks of pandemic diseases, such as the coronavirus, have prompted many to ask why god allowsor even causespandemic diseases and whether such illnesses are a sign of the end times. A general lack of coordination and an unsteady gait often follow. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Those with hd may show shrinkage of some parts of the brainparticularly two areas known as the caudate nuclei and putamenand enlargement of fluidfilled cavities within the brain. Huntingtons disease, hereditary, acute disturbance of the central nervous system usually beginning in middle age and characterized by involuntary muscular movements and progressive intellectual deterioration. Huntington disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinicalresearch specialists looking to expand their knowledge base of huntington disease information, as well as solid groundwork for advanced students from various backgrounds neurology, psychiatry, neuropsychology, genetics. The huntington society of canada is committed to working with families affected by hd and health and social services professionals to enable them to better understand huntington disease. Huntington disease hd is a devastating neurodegenerative disease that derives from cag repeat expansion in the huntingtin gene. The recent identification of the faulty gene involved has made the diagnosis of this. If you read george huntingtons original paper on the disease from back in 1872, his description of the condition remains pretty much spot on as to how the disease is described today. It is about creating awareness and giving the families affected by huntingtons disease a voice to a situation that few understand including friends, family, co.
This guide is a quick introduction to the american psychological association apa style for references and citations. If the child inherits the gene, hd symptoms will develop. Huntingtons disease hd is a chronic, neurodegenerative brain disease. Huntingtons disease hd, also known as huntingtons chorea, is an inherited disorder that results in the death of brain cells. Early symptoms of hd may include uncontrolled movements, clumsiness, and balance problems. Computed tomography ct and magnetic resonance imaging mri provide excellent images of brain structures with little if any discomfort. A person who has the faulty hd gene has a 50% chance of passing it on to each of their children. With the exception of genes on the sex chromosomes, a person inherits two copies of every gene one copy from each parent. Huntingtons disease is a genetically inherited condition which results in severe nervecell damage in the brain. The mean age of onset is 35 to 44 years and the median survival time is 15 to 18 years after onset. Huntingtons disease hd is caused by a dominant mutation in htt, the hd gene. Huntingtons disease core concepts and current advances.
Neurobiology of huntingtons disease ncbi bookshelf. Caviness, in neurology and clinical neuroscience, 2007. Historical aspects 1872 george huntington, md, described a. People at risk of inheriting the faulty hd gene can have genetic testing done to. About thirty thousand 30,000 americans have hd and about one hundred and fifty thousand 150,000 more are at risk of inheriting the disease from a parent. Huntingtons disease symptoms and causes mayo clinic. Researchers have developed a novel measure of disease progression for huntingtons disease, which enabled them to identify a genetic modifier associated with how rapidly the. Brenda kelley kim while there are many neurodegenerative diseases that can devastate patients and families, huntingtons disease remains one of the more severe conditions to impact the brain, and, in turn, the lives of family members and patients who must deal with it. This study aimed to gain a better understanding of behavioral abnormalities in huntington disease hd and to develop a method for reliably assessing these changes. That means the nerve cells in your brain break down over time. Research paper on huntingtons disease 10 october 2016 huntingtons disease is a hereditary brain disorder that is progressive in neurodegeneration. Huntington disease hd is an autosomaldominant disorder, characterized as disease of progressive brain degeneration in late adulthood with subsequent brain atrophy.
The affected areas of degeneration are the basal ganglia, which play an important role in the control of movement. Huntingtons disease begins to affect speech and language communication in the early stage but gradually becomes more intense throughout each stage as the disease progresses. Handbook of disease burden and quality of life measures. Huntington disease is a progressive brain disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability cognition adultonset huntington disease, the most common form of this disorder, usually appears in a persons thirties or forties.
Citing sources in apa style libguides tilburg university. Huntington s disease is an autosomal dominant disorder, which means that a person needs only one copy of the defective gene to develop the disorder. Huntingtons disease background huntingtons disease is inherited as an autosomal dominant disease that gives rise to progressive, elective localized neural cell death associated with choleric movements uncontrollable movements of the arms, legs, and face and dementia. Always seek the advice of your physician or other qualified health provider with any. About 25,000 americans have it and another 60,000 or so will carry. Books vancouver referencing style library guides at university of. Movement behavior thinking, understanding, learning, remembering personality. Huntington s disease books meet your next favorite book.
Books ama citation style research guides at george. It is one of the more common inherited brain disorders. Diagnostic criteria for huntingtons disease based on. For example, to cite both print books and ebooks, use the books and reference works category and then choose the appropriate type of work i.
Huntington s disease hd, also known as huntington s chorea, is an inherited disorder that results in the death of brain cells. The clinical syndrome consists of progressive personality changes. Prevalence in the caucasian population is estimated at 110,0001. An inherited disorder characterized by neuronal dysfunction and degeneration in striatum and cerebral cortex. Terms in this set 11 huntingtons disease definition. The prevalence is estimated at 5 to 10 per 100,000 individuals in the united states, 8 per 100,000 people in the united kingdom, and 1 per 100,000 individuals in japan. People are born with the defective gene, but symptoms usually dont appear until middle age. Oculomotor control in asymptomatic and recently diagnosed individuals with the genetic marker for huntingtons disease. The aan is dedicated to promoting the highest quality patientcentered neurologic care. Is huntingtons disease more common than we thought. It does not provide medical advice, diagnosis or treatment.
Huntington disease hd is a progressive disorder of motor, cognitive, and psychiatric disturbances. Pestka is a clinical nurse specialist and an assistant professor of nursing at the mayo. Sportsman is a staff nurse in the medical psychiatric program and elizabeth l. The diagnosis of hd rests on positive family history, characteristic clinical findings, and the detection of an expansion of. Reference examples apa style american psychological. Citation examples apa 6th libguides at seminole state college. Huntington s disease has a broad impact on a persons functional abilities and usually results in movement, thinking cognitive and psychiatric disorders. As the disease advances, uncoordinated, jerky body movements become more apparent. It is affected by causing muscle weakness, dysarthria, apraxia, perseveration, weaker rate of control, poor voice quality, misarticulation, discoordination of breathing. Diagnostic criteria for huntingtons disease based on natural history ralf reilmann, md,1,2 blair r. This discovery opens possibilities for treatment based on silencing of the diseasecausing allele or with compounds that reduce the production of diseasecausing mrna andor protein. Publications product categories huntingtons disease.
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